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KMID : 0043320030260020151
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Archives of Pharmacal Research
2003 Volume.26 No. 2 p.151 ~ p.156
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Inhibitory Effects of Luteolin Isolated from lxeris sonchifolia Hance on the Proliferation of HepG2 Human Hepatocellular Carcinoma Cells
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Yee SB
Lee JH/Chung HY/Im KS/Bae SJ/Choi JS/Kim ND
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Abstract
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We investigated the anti-proliferative effects of luteolin and apigenin, isolated lxeris sonchifolia from Hance, on HepG2 human hepatocellular carcinoma cells. In MTT ass ay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cycle arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor p21WAF1/CIP1 protein. These data suggest that luteolin may have potential as an anti-cancer agent.
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